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Tianmeng, Sun
Chemistry / Inorganic Chemistry
Nanomaterials, Cancer Therapy, Immunotherapy
Contact Information
Email    tsun41@jlu.edu.cn
Office     307-2 National-Local Joint Engineering Laboratory of Animal Models for Human Diseases,Jilin Unversity, 0431-80539006               
Lab        208 National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, 0431-80539024
Short Biography
Dr. Tianmeng Sun obtained his PhD. in Cell Biology from University of Science and Technology of China,2011. Then, he was trained with Dr. Younan Xia at Georgia Institute of Technology, U.S.A. In 2014, Dr. Tianmeng Sun became a principal investigator at Jilin University. Since 2019, he has been the Deputy Director of the Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education.
Research Interest
The principal effort of our research program is on the development of nanomaterials for safe and efficient immunotherapy for tumors, autoimmune diseases and organ transplantation. Specifically, we have three major focuses: 1) Reprogram the immune microenvironment of tumors; 2) induce immune tolerance; 3) develop vaccine adjuvants.
Honors & Awards
2014 NSFC Outstanding Young Scientists Fund;
2014 Changbai Mountain Distinguished Professorship;
2022 First Prize of Jilin Provincial Natural Science Award.

[1] H. Chen, X. Cong1 C. Wu, X. Wu, J. Wang, K. Mao, J. Li, G. Zhu, F. Liu, X. Meng, J. Song, X. Sun, X. Wang, S. Liu, S. Zhang, X. Yang, Y. Song,* Y.-G. Yang,* T. M. Sun.* Intratumoral Delivery of CCL25 Enhances Immunotherapy Against Triple Negative Breast Cancer by Recruiting CCR9+ T cells. Science Advances 2020, 6(5), eaax4690.
[2] Z. Li, W. Xu, J. Yang, J. Wang, J. Wang, G. Zhu, D. Li,* J. Ding,* T. M. Sun *. Tumor Microenvironments-Adapted Polypeptide Hydrogel/Nanogel Composite Boosts Antitumor Molecular Targeted Inhibition and Immunoactivation. Advanced Materials, 2022, 34, 2200449.
[3] Y. Hou, Y. Xin, S. Liu, Y. Li, X. Meng, J. Wang, Z. Xu, T. M. Sun*, Y.-G. Yang*. A biocompatible nanoparticle-based approach to inhibiting renal ischemia reperfusion injury in mice by blocking thrombospondin-1 activity. American Journal of Transplantation, 2022, DOI: 10.1111/ajt.17052.
[4] S. Liu, J. Liu, H. Li, K. Mao, H. Wang, X. Meng, J. Wang, C. Wu, H. Chen, X. Wang, X. Cong, Y. Hou, Y. Wang, M. Wang,* Y.-G. Yang,* T. M. Sun*. An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma immunotherapy. Biomaterials, 2022, 287, 121645.
[5] X. Sun, Z. Cao, K. Mao, C. Wu, H. Chen, J. Wang, X. Wang, X. Cong, Y. Li, X. Meng,* X. Yang,* Y.-G. Yang,* T. M. Sun.* Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib. Biomaterials, 2020, 240, 119845.
[6] X. Cong, H. Tian, S. Liu, K. Mao, H. Chen, Y. Xin, F. Liu, X. Wang, X. Meng, G. Zhu, J. Wang, X. Gao, H. Tan, Y.-G. Yang, T. M. Sun.* Cationic Liposome/DNA Complexes Mediate Antitumor Immunotherapy by Promoting Immunogenic Tumor Cell Death and Dendritic Cell Activation. ACS Applied Materials & Interfaces, 2020, 12, 28047–28056.
[7] Y. Xin, Y. Hou, X. Cong, H. Tan, J. Wang, K. Mao, X. Wang, F. Liu, Y.-G. Yang* T. M. Sun*, Kidney functional stages influence the role of PEG end-group on the renal accumulation and distribution of PEGylated nanoparticles. Nanoscale, 2022, 14, 9379-9391.
[8] X. Wu, H. M. Chen, C. X. Wu, J. L. Wang, S. Zhang, J. Gao, H. D. Wang, T. M. Sun,* Y. G. Yang,* Inhibition of intrinsic coagulation improves safety and tumor-targeted drug delivery of cationic solid lipid nanoparticles. Biomaterials 2018, 156, 77-87.
[9] Y. D. Yao,# T. M. Sun,# S. Y. Huang, S. Dou, L. Lin, C. Q. Mao, F. Y. Yu, M. S. Zeng, J. Y. Zang, Q. Liu, F. X. Su, P. Zhang, J. Lieberman,* J. Wang,* E. W. Song,* Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis. Science Translational Medicine 2012, 4, 30-48.
[10] T. M. Sun,# Y. S. Zhang,# B. Pang,# D. C. Hyun,# M. Yang, Y. Xia,* Engineered Nanoparticles for Drug Delivery in Cancer Therapy. Angewandte Chemie International Edition 2014, 53, 12320-64.

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