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Xiaoxia Han
Physical Chemistry
Surface-enhanced Raman scattering spectroscopy Bioanalytical chemistry
a href="mailto:hanxiaoxia@jlu.edu.cn">hanxiaoxia@jlu.edu.cn
Contact Information
Email    hanxiaoxia@jlu.edu.cn
Office     Room A305, State Key Laboratory of Supramolecular Structure and Materials, Jilin University               
Lab        State Key Laboratory of Supramolecular Structure and Materials,
Jilin University, 2699 Qianjin Street, Changchun 130012, China
Short Biography
Dr. Xiaoxia Han obtained a bachelor degree in bioscience from Changchun Normal University in 2003, and got a doctoral degree in physical chemistry from Jilin University in 2009. As a postdoctoral fellow of the Japanese Society for Promotion of Science, she spent two years in chemistry department of Kwansei Gakuin University, Japan. In 2011, she, as a research Fellow of the Alexander von Humboldt Foundation, worked in Max-Volmer-Laboratory for Biophysical Chemistry, Technical University of Berlin, Germany. In December 2013, She started to work at State Key Laboratory of Supramolecular Structure and Materials, Jilin University.
Research Interest
We focus on surface-enhanced Raman scattering (SERS) from bionanomaterials and their applications. In combination of nanomaterial synthesis, SERS and bioanalytical techniques, we are trying to investigate the properties of biocompatible nanomaterials, their supermolecular assembly with biomolecules, and their applications in biophysics and biochemistry.
Honors & Awards
1.Excellent doctoral dissertation of Jilin Province and nominated as one of The National 100 Excellent Doctoral Dissertation, 2011.
2.Postdoctoral fellowship of the Alexander von Humboldt Foundation, 2011.
3.Postdoctoral fellowship of the Japanese Society for Promotion of Science, 2009.
4.One of outstanding students of Baosteel Education Foundation, China Baosteel Education Foundation, 2008.
5.Scholarship for government-sponsored overseas study, China Scholarship Council, 2007.

[1]Zhu, J.; Jiang, M.; Ma, H.; Zhang, H.; Cheng, W.; Li, J.; Cai, L.; Han, X. X.; Zhao, B. Redox-State-Mediated Regulation of Cytochrome c Release in Apoptosis Revealed by Surface-Enhanced Raman Scattering on Nickel Substrates. Angew. Chem. Int. Ed. 2019, 58, 16499 –16503.
[2]Zhang, H.; Kou, Y.; Li, J.; Chen, L.; Mao, Z.; Han, X. X.; Zhao, B.; Ozaki, Y. Nickel Nanowires Combined with Surface-Enhanced Raman Spectroscopy: Application in Label-Free Detection of Cytochrome c-Mediated Apoptosis. Anal. Chem. 2019, 91, 1213-1216.
[3]Ma, H.; Tang, X.; Liu, Y.; Han, X. X.; He, C.; Lu, H.; Zhao, B. Surface-Enhanced Raman Scattering for Direct Protein Function Investigation: Controlled Immobilization and Orientation. Anal. Chem. 2019, 91, 8767-8771.
[4]Ma, H.; Sun, X.; Chen, L.; Han, X. X.; Zhao, B.; Lu, H.; He, C. Antibody-Free Discrimination of Protein Biomarkers in Human Serum Based On Surface-Enhanced Raman Spectroscopy. Anal. Chem., 2018, 90, 12342-12346.
[5]Mao, Z.; Liu, Z.; Yang, J.; Han, X.; Zhao, B.; Zhao, C. In Situ Semi-Quantitative Assessment of Single-Cell Viability by Resonance Raman Spectroscopy. Chem. Commun., 2018, 54, 7135-7138.
[6]Ma, H.; Sun, X.; Chen, L.; Cheng, W.; Han, X. X.; Zhao, B.; He, C. Multiplex Immunochips for High-Accuracy Detection of AFP-L3% based on Surface-Enhanced Raman Scattering: Implications for Early Liver Cancer Diagnosis. Anal. Chem., 2017, 89, 8877-8883.
[7]Han, X. X.; Chen, L.; Kuhlmann, U.; Schulz, C.; Weidinger, I. M.*; Hildebrandt, P.*, Magnetic Titanium Dioxide Nanocomposites for Surface-Enhanced Resonance Raman Spectroscopic Determination and Degradation of Toxic Anilines and Phenols, Angew. Chem. Int. Ed., 53, 2481 –2484, 2014.
[8]Han, X. X.; Köhler, C.; Kozuch, J.; Kuhlmann, U.; Paasche, L.; Sivanesan, A.; Weidinger, I. M.*; Hildebrandt, P.*, Potential-Dependent Surface-Enhanced Resonance Raman Spectroscopy at Nanostructured TiO2: A Case Study on Cytochrome b5, Small, 9, 4175-4181, 2013.
[9]Han, X. X.; Schmidt, A. M.; Marten, G.; Fischer, A.; Weidinger, I. M.*; Hildebrandt, P. *, Magnetic Ag Hybrid Nanoparticles for SERR Spectroscopic Detection and Decontamination of Small Toxic Molecules, ACS Nano, 7, 3212–3220, 2013.
[10]Han, X. X.*; Zhao, B.; Ozaki, Y.*, Label-Free Detection in Biological Applications of Surface-Enhanced Raman Scattering, TrAC-Trends Anal. Chem., 38, 67-78, 2012.

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