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Wenke Zhang
Chemistry /Polymer Chemistry and Physics

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Contact Information
Email    zhangwk@jlu.edu.cn
Office     B200 Supramolecular Building
Lab        B416, B200-1
             Supramolecular Building
Short Biography
Dr. Wenke Zhang obtained his master and Ph. D. degree from Jilin University under the supervision of Prof. Xi Zhang in 1997 and 2002, respectively. During 2001-2002, he worked as a joint-training Ph. D. student in Prof. Hermann E. Gaub’s group in Munich (LMU). Then, he did his postdoc in the University of Nottingham (UK) between 2003-2007. Since June 2007, he moved back to Jilin University and become a faculty member of the State Key Laboratory of Supramolecular Structure and Materials.
Research Interest
Single-molecule study has become one of the hot research areas during recent years. Such study can provide valuable information, which could not be obtained by conventional ensemble measurements, for example the transition state of the protein folding/unfolding. We use atomic force microscopy (AFM), single-molecule force spectroscopy and related techniques to solve the following problems at single-molecule level: 1) the driving force for supramolecular assembly; 2) polymer crystallization and melting; 3) virus assembly and disassembly; 4) mechanochemistry of macromolecules. These studies will deepen our understanding on supramolecular structure and the dynamic process of supramolecular assembly. The information obtained will help us gain controls on the corresponding supramolecular structure and function.
Honors & Awards
1) New Century Excellent Talents in Universities (2011),
2) The Awardee of the National Science Funds for Distinguished Young Scholars (2015),
3) Ten Thousand Talent Plan (2018)

[1] X. J. Lyu, Y. Song, W. Feng, W. K. Zhang*, Direct observation of single-molecule stick-slip motion in polyamide single crystals, ACS Macro Lett., 2018, 7, 762−766.
[2] P. Yang, Y. Song, W. Feng, W. K. Zhang*, Unfolding of a single polymer chain from the single crystal by air-phase single-molecule force spectroscopy: toward better force precision and more accurate description of molecular behaviors, Macromolecules, 2018, 51, 7052−7060.
[3] Z. D. Li, Y. Song, A. S. Li, W. Q. Xu, W. K. Zhang*, Direct observation of the wrapping/unwrapping of ssDNA around/from a SWCNT at the single-molecule level: towards tuning the binding mode and strength, Nanoscale, 2018, 10, 18586-18596.
[4] W. Feng, Z. G. Wang, W. K. Zhang*, Effect of chain conformation on the single-molecule melting force in polymer single crystals: steered molecular dynamics simulations study, Langmuir, 2017, 33, 1826−1833.
[5] H. Zhang, X. Li, Y. J. Lin, F. Gao, Z. Tang, P. F. Su, W. K. Zhang*, Y. Z. Xu, W. G. Weng*, R. Boulatov*, Multi-modal mechanophores based on cinnamate dimers, Nat. Commun., 2017, 8, 1147.
[6] X. L. Kou, W. Zhang, W. K. Zhang*, Quantifying the interactions between PEI and double-stranded DNA: toward the understanding of the role of PEI in gene delivery, ACS Appl. Mater. Interfaces 2016, 8, 21055−21062.
[7] Y. R. Xue, X. Li, H. B. Li, W. K. Zhang*, Quantifying thiol-gold interactions towards the efficient strength control, Nat. Commun., 2014, 5:4348.
[8] N. N. Liu, Y. Chen, B. Peng, Y. Lin, Q. Wang*, Z. H. Su, W. K. Zhang*, H. B. Li, J. C. Shen, Single-molecule force spectroscopy study on the mechanism of RNA disassembly in tobacco mosaic virus, Biophys. J., 2013, 105, 2790-2800.
[9] N. N. Liu, B. Peng, Y. Lin, Z. H. Su, Z. W. Niu, Q. Wang, W. K. Zhang*, H. B. Li, J. C. Shen, Pulling genetic RNA out of tobacco mosaic virus using single-molecule force spectroscopy, J. Am. Chem. Soc., 2010, 132, 11036-11038.
[10] K. Liu, Y. Song, W. Feng, N. N. Liu, W. K. Zhang*, X. Zhang, Extracting a single polyethylene oxide chain from a single crystal by a combination of atomic force microscopy imaging and single-molecule force spectroscopy: toward the investigation of molecular interactions in their condensed states, J. Am. Chem. Soc., 2011, 133, 3226-3229.

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