The principal effort of our research program is on the design of new foldamers that are applicable for the development of bio-inspired supramolecular chemistry. Specifically, the general nature in physics and chemistry from the bio-inspired supramolecular system, such as aggregation morphology, supramolecular chirality, and supramolecular catalysis, would be explored. The research in detail includes following.

1. Development of new methods of supramolecular polymerization

2. Supramolecular engineering of foldamers

3. Artificial enzymes based on helical architectures

2009 Marie Curie International Incoming Fellowship by European Commission FP7

[ Selected Publications ]
1）Shuaiwei Qi, Chenyang Zhang, Hao Yu, Jing Zhang, Tengfei Yan, Ze Lin, Bing Yang, and Zeyuan Dong*, Foldamer-based potassium channels with high ion selectivity and transport activity, J. Am. Chem. Soc. 2021, 143, 3284−3288.
2) Chenyang Zhang, Jun Tian, Shuaiwei Qi, Bing Yang, and Zeyuan Dong*, Highly efficient exclusion of alkali metal ions via electrostatic repulsion inside positively charged channels, Nano Lett. 2020, 20, 3627−3632.
3) Jing Zhang, Shuaiwei Qi, Chenyang Zhang, Zengming Fan, Qinwen Ding, Shizhong Mao, Zeyuan Dong*, Controlling keto−enol tautomerism of ureidopyrimidinone to generate a single-quadruple AADD-DDAA dimeric array, Org. Lett. 2020, 22, 7305−7309.
4）Chenyang Zhang, Xiaoli Deng, Chenxi Wang, Chunyan Bao, Bing Yang, Houyu Zhang, Shuaiwei Qi, Zeyuan Dong*, Helical supramolecular polymer nanotubes with wide lumen for glucose transport: Towards the development of functional membrane-spanning channels, Chem. Sci. 2019, 10, 8648−8653.
5）Chao Zeng, Chenyang Zhang, Junyan Zhu, Zeyuan Dong*, Supramolecular polymerization driven by the dimerization of single-stranded helix to double-stranded helix, Chinese J. Polym. Sci. 2018, 36, 261−265.
6）Chao Lang, Xiaoli Deng, Feihu Yang, Bing Yang, Wei Wang, Shuaiwei Qi, Xin Zhang, Chenyang Zhang, Zeyuan Dong*; Junqiu Liu*; Highly selective artificial potassium ion channels constructed from pore-containing helical oligomers, Angew. Chem. Int. Ed. 2017, 56, 12668−12671.
7）Chao Lang, Wenfang Li, Zeyuan Dong*, Xin Zhang, Feihu Yang, Bing Yang, Xiaoli Deng, Chenyang Zhang, Jiayun Xu, Junqiu Liu*, Biomimetic transmembrane channels with high stability and transporting efficiency from helically folded macromolecules, Angew. Chem. Int. Ed. 2016, 55, 9723−9727.
8) Junyan Zhu, Zeyuan Dong*, Shengbin Lei, Lili Cao, Bing Yang, Wenfang Li, Yuanchao Zhang, Junqiu Liu*, Jiacong Shen, Design of aromatic helical polymers for stm visualization: Imaging of single and double helices with a pattern of pi stacking, Angew. Chem. Int. Ed. 2015, 54, 3097−3101.
9) Laurence Delauriere#, Zeyuan Dong#, Katta Laxmi-Reddy, Frederic Godde, Jean-Jacques Toulme*, Ivan Huc*, Deciphering aromatic oligoamide foldamer-dna interactions, Angew. Chem. Int. Ed. 2012, 51, 473−477. (co-first author)
10) Zeyuan Dong, Quan Luo, Junqiu Liu*, Artificial enzymes based on supramolecular scaffolds, Chem. Soc. Rev. 2012, 41, 7890−7908.