报告题目：The role of KOtBu in transition metal-free coupling reactions between haloarenes and arenes

报 告 人：Professor JOHN A. MURPHY

                    University of Strathclyde

报告地点：无机超分子楼A301会议室

报告时间：8月30日（星期五）上午10:00

报告摘要：

Many reactions lead to coupling of haloarenes to arenes, using potassium tert-butoxide as base, and one of a variety of organic compounds, as additive. The organic additives react with the base to form strong organic electron donors in situ that initiate the BHAS (base-induced homolytic aromatic substitution) coupling reaction by converting the haloarene to an aryl radical. This lecture presents our perspectve on the wide range of organic additives that can be used, and the organic electron donors that are formed.

报告人简介：

University Education:
1972-1976 University of Dublin.
Awarded B.A. (Moderatorship) First Class.
Awards Held: Department of Education Scholar (1972-1976).
University of Dublin Foundation Scholar (1974-1979). Goulding Scholar
(1975); Gold Medallist of the University (1976); Cocker Medallist (1976).
1976-1979 University of Cambridge. (Hutchinson Research Studentship.)
Awarded Ph.D. in Organic Chemistry (Prof. Jim Staunton, A New
Synthesis of Pretetramid)

Appointments Held:
2016-2020 Head of Section, Synthesis and Catalysis, Dept. of Pure and Applied Chemistry.
2013-2016 Head of Department of Pure and Applied Chemistry, University of Strathclyde.
2007-2012 Director, Glasgow Centre for Physical Organic Chemistry.
2010-2016 Head of Organic Chemistry, Dept. of Pure and Applied Chemistry.
2007-2013 Deputy Head of Department, Dept. of Pure and Applied Chemistry.
2006-2008 Director, WestCHEM Research School.
2004-2006 Deputy Director, Research School.
1995- to date Merck-Pauson Professor, University of Strathclyde.
1994-1995 Reader, University of Nottingham.
1983-1994 Lecturer, University of Nottingham.
1982-1983 College Lecturer, Jesus College, Oxford.
1980-1983 Departmental Demonstrator, University of Oxford (with Prof. J. E. Baldwin)
1979-1980 Izaak Walton Killam Fellowship, University of Alberta with (Prof. J.W. Lown)

Publications:
• Rohrbach, S.; Shah, R. S.; Tuttle, T.; Murphy, J. A., Neutral Organic Super Electron Donors Made Catalytic, Angew. Chem. Int. Ed., 2019. (Highlighted as a very important publication (VIP))
• Rohrbach, S.; Smith, A. J.; Pang, J. H.; Poole, D. L.; Tuttle, T.; Chiba, S.; Murphy, J. A., Concerted Nucleophilic Aromatic Substitution Reactions. Angew. Chem. Int. Ed., 2019.
• Turner, O. J.; Murphy, J. A.; Hirst, D. J.; Talbot, E. P. A., Hydrogen Atom Transfer-Mediated Cyclisations of Nitriles, Chem. Eur. J., 2018.
• Barham, J. P.; Dalton, S. E.; Allison, M.; Nocera, G.; Young, A.; John, M. P.; McGuire, T. M.; Campos, S.; Tuttle, T.; Murphy, J. A., Dual Roles for Potassium Hydride in Haloarene Reduction: CSNAr and SET Reduction via Organic Electron Donors Formed in Benzene, J. Am. Chem. Soc., 2018.
• Nocera, G.; Young, A.; Palumbo, F.; Emery, K. J.; Coulthard, G.; McGuire, T. M.; Tuttle, T.; Murphy, J. A., Electron Transfer reactions: KOtBu (but not NaOtBu) Photo-reduces Benzophenone, under Activation by Visible Light, J. Am. Chem. Soc., 2018.
• Dalton, S. E.; Dittus, L.; Thomas, D. A.; Convery, M. A.; Nunes, J.; Bush, J. T.; Evans, J. P.; Werner, T.; Bantscheff, M.; Murphy, J. A.; Campos, S., Selectively targeting the kinome-conserved lysine of PI3Kdelta as a general approach to covalent kinase inhibition, J. Am. Chem. Soc., 2018.
• Smith, A. J.; Young, A.; Rohrbach, S.; O'Connor, E. F.; Allison, M.; Wang, H.-S.; Poole, D. L.; Tuttle, T.; Murphy, J. A., Electron Transfer and Hydride Transfer Pathways in the Stoltz-Grubbs Reducing System (KOtBu-Et3SiH), Angew. Chem. Int. Ed., 2017.

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