报告题目：Construction of metalloenzymes: coordination chemistry and catalytic activities in proteins

报告人：渡边芳人教授

报告时间：2016.09.15（星期四）下午3:00

报告地点：无机/超分子楼二楼圆形报告厅

报告摘要：

Based on catalytic reactions, coordination chemistry, and organometallic chemistry, we are able to design enzymes

which catalyze nobel reactions such as oxidation, hydrogenation, C-C coupling, and polymerization.

Keywords: Catalytic Chemistry, Metal Complex, Organometallic Chemistry, Mutation, Oxidation, Reduction, Suzuki Coupling，polystyrene, Myoglobin, Heme Enzyme, Ferritin

报告人简介：

教育背景

1972 - 1976 B.Sc. Tohoku University

1977 - 1982 Dr. Sc. Tsukuba University

工作经历

1982 Postdoctoral Fellow, University Michigan

1985 Res. Staff Member, Princeton University, Princeton, NJ, USA

1987 Assistant Professor, School of Medicine, Keio University

1990 Associate Professor, Kyoto University

1994 Professor, Institute for Molecular Science

2002 - present Professor, Nagoya University

2009 - present vice-President, Nagoya University

研究兴趣

Bioinorganic Chemistry, Enzymatic Reaction Mechanism, Biological Oxidation Chemistry

发表文章

• Y. Watanabe et al. "Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp) Bound to Synthetic Metal Complexes," Angew. Chem. Int. Ed., 53, 2862–2866 (2014).

• Y. Watanabe et al. "Highly Selective Hydroxylation of Benzene to Phenol by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules," Angew. Chem. Int. Ed., 52, 6606-6610 (2013).

• Y. Watanabe et al. “Crystal Structure of H2O2-Dependent Cytochrome P450SPα with its Bound Fatty Acid Substrate: Insight into the regioselective hydroxylation of fatty Acids at the α Position,” J. Biol. Chem., 286, 29941-29950 (2011).

• Y. Watanabe et al. "Reactivities of Oxo and peroxo Intermediates Studied by Hemoprotein Mutants," Acc. Chem. Res., 40, 554-562 (2007).

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