报告题目：Mussel-inspired polydopamine/catecholamine surface chemistry and Hemostats
Department of Chemistry, Korea Advanced Institute of Sci. Tech (KAIST)
Catecholamine polymers have become emerging biopolymers for material-independent adhesive properties. Well-known examples are poly(dopamine), pDA and poly(norepinephrine), pNOR. These polymers have mostly formed and subsequently used by in situ polymerization from the corresponding catecholamine monomers of dopamine or norepinephrine. These exhibited excellent in vivo compatibility and biodegradability. Other types of catecholamine polymers are prepared by chemical conjugation of catechol along the backbone of cationic polymers such as chitosan or poly(ethylenimine). They demonstrated excellent adhesive properties but also exhibited additional useful functions in a variety of biomedical applications. For example, the surface coating of poly(ethylenimine)-catechol onto adeno-associate virus generated sticky virus for local gene delivery. Also, catechol conjugation to chitosan dramatically increased water solubility of chitosan (~ 60 mg/mL at pH = 7). Before the catechol conjugation, the chitosan is completely water insoluble at the neutral pH. This favorable property change of the chitosan-catechol conjugate opens new opportunities for chitosan to be applied to various biomedical applications such as hemostatic agents.