报告题目：Recent Progress on Activatable Photosensitizers and Fluorescent Probes
报 告 人： Prof. Juyoung Yoon
Ewha Womans University, Korea
Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field of precision nanomedicine.1 Here, we develop a “one-for-all” nanomaterial (NanoPcTBs) that self-assembles from flexible and versatile phthalocyanine building blocks.2 Fluorescence and reactive oxygen species (ROS) generation could be triggered depending on a targeted, protein-induced, partial disassembly mechanism, which creates opportunities for low-background fluorescence imaging and activatable photodynamic therapy (PDT). We also reported a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which have the capability of undergoing nucleic acid-responsive disassembly.3 On the other hand, the in vivo specific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, was recently confirmed using an inducible transgenic mouse system.4 In addition, we demonstrated that a new, nanostructured phthalocyanine assembly, NanoPcA, inherently possesses the ability to promote highly efficient ROS generation via the type I mechanism.5 Recently, we also demonstrated the first comprehensive molecular design of heavy-atom-free triplet PSs based on thiocarbonyl naphthalimides with excellent potential in PDT.6 Finally, recent progress from our group on the fluorescent probes based on N-heterocyclic carbene (NHC) boranes for HOCl7 will be also presented.
1 Li, X.; Lee, S.; Yoon, J. Chem. Soc. Rev. 2018, 47, 1174-1188.
2 Li, X.; Kim, C-y.; Lee, S.; Lee, D.; Chung, H.-M.; Kim, G.; Heo, S.-H.; Kim, C.; Hong, K.-S.; Yoon, J. J. Am. Chem. Soc. 2017, 139, 10880-10886.
3 Li, X.; Yu, S.; Lee, D.; Kim, G.; Lee, B.; Cho, Y.; Zheng, B.-Y.; Ke, M.-R.; Huang, J.-D.; Nam, K. T.; Chen, X.; Yoon, J. ACS Nano 2018, 12, 681-688.
4 Li, X.; Yu, S.; Lee, Y.; Guo, T.; Kwon, N.; Lee, D.; Yeom, S. C.; Cho, Y.; Kim, G.; Huang, J.-D.; Choi, S.; Nam, K. T.; Yoon, J. J. Am. Chem. Soc. 2019, 141, 1366-1372. (Cover)
5 Li, X.; Lee, D.; Huang, J.-D.; Yoon, J. Angew. Chem. Int. Ed. 2018, 57, 9885-9890. (Hot Paper)
6 Nguyen, V.-N.; Qi, S.; Kim, S.; Kwon, N.; Kim, G.; Yim, Y.; Park, S.; Yoon, J. J. Am. Chem. Soc. 2019, 141, 16243-16248.
7 Pak, Y. L.; Park, S. J.; Wu, D.; Cheon, BH.; Kim, H. M.; Bouffard, J.; Yoon, J. Angew. Chem. Int. Ed. 2018, 57, 1567-1571.
CURRICULUM VITAE – Prof. Juyoung Yoon
Work Address： Department of Chemistry and Nano Science，Ewha Womans University, Seoul 120-750, Korea
Telephone： +82-2-3277-2400， E-mail： email@example.com
Ph.D. The Ohio State University (Organic Chemistry)，“Studies on Bioorganic Chemsitry”
Fluorescent Probes; Activatable Photosensitizers; Theranostics
350 SCI research papers. (h-index: 98)
RECENT SELECTIVE PUBLICATIONS
1. “An Emerging Molecular Design Approach to Heavy-Atom-Free Photosensitizers for Enhanced Photodynamic Therapy under Hypoxia” J. Am. Chem. Soc. 2019, 141, 16243-16248.
2. “In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach” J. Am. Chem. Soc. 2019, 141, 1366–1372. (Cover)
3. “N-Heterocyclic Carbene Boranes as Reactive Oxygen Species-Responsive Materials: Application to the Two-Photon Imaging of Hypochlorous Acid in Living Cells and Tissues” Angew. Chem. Int. Ed. 2018, 57, 1567 –1571.
4. “Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy” ACS Nano, 2018, 12, 681-688.
5. “Nanostructured Phthalocyanine Assemblies with Protein-Driven Switchable Photoactivities for Biophotonic Imaging and Therapy” J. Am. Chem. Soc. 2017, 139, 10880–10886
CURRENT SCIENTIFIC ACTIVITIES
Editorial Advisory Board; Chemical Society Reviews (RSC), Scientific Reports (Nature Publishing Group), ACS Applied Materials & Interfaces (ACS), ACS Sensors (ACS), Chem (Cell Press), Sensors and Actuators B (Elsevier), Materials
Chemistry Frontiers (RSC), Chinese Chemical Letters (Elsevier), ACS Omega (ACS), ACS Applied Bio Materials (ACS)
2015 – Present Executive Editor; Dyes & Pigments (Elsevier)
2017 – Present Associate Editor; Coordination Chemistry Reviews (Elsevier)
2014 – Present Fellow of Royal Society of Chemistry (RSC)
2014 – Present a member of Korean Academy of Science and Technology
listed as highly cited researcher in chemistry of 2014-2019
2019.10: 2nd Korea Toray Science Award (Korea Toray Science Foundation)
2016. 5.; Ewha Academic Award
2016. 4.: Korean Chemical Society Award
2014.3 - present: “Distinguished Professorship” by Ewha Womans University
2012. 11: “Knowledge Creation Grand Prize” by Ministry of Science and Technology of Korea
2012.9-2014.2: “Future Distinguished Professorship” by Ewha Womans University
2011. 10: “Monthly Best Scientist Award” by Ministry of Science and Technology of Korea
2008: “Shim Sang Chul Award” from Organic Division of Korean Chemical Society