Topic：Construction of metalloenzymes: coordination chemistry and catalytic activities in
Speaker：Prpf. Yoshihito Watanabe
Based on catalytic reactions, coordination chemistry, and organometallic chemistry, we are able
to design enzymes
which catalyze nobel reactions such as oxidation, hydrogenation, C-C coupling, and
Keywords: Catalytic Chemistry, Metal Complex, Organometallic Chemistry, Mutation, Oxidation,
Reduction, Suzuki Coupling，polystyrene, Myoglobin, Heme Enzyme, Ferritin
1972 - 1976 B.Sc. Tohoku University
1977 - 1982 Dr. Sc. Tsukuba University
1982 Postdoctoral Fellow, University Michigan
1985 Res. Staff Member, Princeton University, Princeton, NJ, USA
1987 Assistant Professor, School of Medicine, Keio University
1990 Associate Professor, Kyoto University
1994 Professor, Institute for Molecular Science
2002 - present Professor, Nagoya University
2009 - present vice-President, Nagoya University
Bioinorganic Chemistry, Enzymatic Reaction Mechanism, Biological Oxidation Chemistry
• Y. Watanabe et al. "Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp) Bound to Synthetic Metal Complexes," Angew. Chem. Int. Ed., 53, 2862–2866 (2014).
• Y. Watanabe et al. "Highly Selective Hydroxylation of Benzene to Phenol by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules," Angew. Chem. Int. Ed., 52, 6606-6610 (2013).
• Y. Watanabe et al. “Crystal Structure of H2O2-Dependent Cytochrome P450SPα with its Bound Fatty Acid Substrate: Insight into the regioselective hydroxylation of fatty Acids at the α Position,” J. Biol. Chem., 286, 29941-29950 (2011).
• Y. Watanabe et al. "Reactivities of Oxo and peroxo Intermediates Studied by Hemoprotein Mutants," Acc. Chem. Res., 40, 554-562 (2007).