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REPORT: Construction of metalloenzymes: coordination chemistry and catalytic activities in
Sep 13, 2016

Topic:Construction of metalloenzymes: coordination chemistry and catalytic activities in

Speaker:Prpf. Yoshihito Watanabe
Time:2016.09.15(Thursday) 3:00pm
Based on catalytic reactions, coordination chemistry, and organometallic chemistry, we are able

to design enzymes
which catalyze nobel reactions such as oxidation, hydrogenation, C-C coupling, and

Keywords:   Catalytic Chemistry, Metal Complex, Organometallic Chemistry, Mutation, Oxidation,

Reduction, Suzuki Coupling,polystyrene, Myoglobin, Heme Enzyme, Ferritin

Bio Information:
1972 - 1976 B.Sc. Tohoku University
1977 - 1982 Dr. Sc. Tsukuba University

Major Experience
1982  Postdoctoral Fellow, University Michigan
1985  Res. Staff Member, Princeton University, Princeton, NJ, USA
1987  Assistant Professor, School of Medicine, Keio University
1990  Associate Professor, Kyoto University
1994  Professor, Institute for Molecular Science
2002 - present Professor, Nagoya University
2009 - present vice-President, Nagoya University

Research Field
Bioinorganic Chemistry, Enzymatic Reaction Mechanism, Biological Oxidation Chemistry

Selected Publications
• Y. Watanabe et al. "Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp) Bound to Synthetic Metal Complexes," Angew. Chem. Int. Ed., 53, 2862–2866 (2014).
• Y. Watanabe et al. "Highly Selective Hydroxylation of Benzene to Phenol by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules," Angew. Chem. Int. Ed., 52, 6606-6610 (2013).
• Y. Watanabe et al. “Crystal Structure of H2O2-Dependent Cytochrome P450SPα with its Bound Fatty Acid Substrate: Insight into the regioselective hydroxylation of fatty Acids at the α Position,” J. Biol. Chem., 286, 29941-29950 (2011).
• Y. Watanabe et al. "Reactivities of Oxo and peroxo Intermediates Studied by Hemoprotein Mutants," Acc. Chem. Res., 40, 554-562 (2007).


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