The research currently concentrates on the biomimetic supramolecular assemblies and their functions. The scientific activities carried on by several labs include as follows: 1) Designing a series of highly efficient supramolecular enzyme mimics with complex and hierarchical structures on the basis of molecular recognition in order to reveal the catalytic mystery of natural enzymes; 2) Using the multiple non-covalent interactions to construct the biosupramolecular assemblies with multi-level and multi-demensional architectures and to realize the integration of multiple functions of the biosupramolecular assemblies as well; 3) Taking various analytic techniques like single molecular force spectroscopy to understand the dynamic principle of supramolecular interactions of the biological systems.
Professor Junqiu Liu's research group has the main research interests including biomimetic systems, biomolecule-based supramolecular self-assembly and bio-nanomaterials. Current research focuses on the design of artificial selenoenzymesand supramolecular enzymes as well asprotein assembly.
Professor Wenke Zhang's research group focuses on the understanding of supramolecular interactions, supramolecular assembled structure and the dynamic assembly/disassembly process of supramolecular assemblies at single molecule level. The melting and crystallization of polymer single crystal and the assembly/disassembly of virus particle are studied using AFM-based single-molecule force spectroscopy. The mechanisms of polymer crystallization and virus disassembly are disclosed.
Professor Yuqing Wu’s research group is centered on understanding how the small molecules to interfere the assembly of virus particles, the function of specific enzymes related to several serious diseases, as well as how to detect these biological and/or medical related targets, both for diagnosis and therapeutics purposes in final.
Dr. Zhijun Chen's research group has been interested in (1) understanding supramolecularstructures in biology, with special focus on protein-protein and protein-small moleculesrecognition in lipid metabolism and mitochondrial function; (2) Modulation of cell metabolism for biofuels and pharmaceuticals productionusing synthetic biology as a tool; and (3) nanomaterial synthesis, assembly and their application in probing, imaging and delivery. The long-term goal of the lab is to generate tools for biomedical and material research.